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OCR: s signs and Patients with neoplasms develop vario s are symptoms, and the major clinical featur derived from the mass effect of the prim .ses, In tumour, its invasion and distant metast variety of addition, neoplasms can produce a wide om the clinical features at sites that are distant f red to as tumour mass; these are collectively refer cts of paraneoplastic syndromes or remote effe aneoplasticmalignancy. Two major categories of pa nd syndrome include humoral syndromes neurogenic syndromes,